John F Hancock Selected Research

ras Proteins

1/2020	RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics.
12/2019	Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling.
1/2018	An oxanthroquinone derivative that disrupts RAS plasma membrane localization inhibits cancer cell growth.
1/2017	Inhibition of RAS function through targeting an allosteric regulatory site.
6/2013	Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function.
1/2013	Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission.
4/2012	Ras trafficking, localization and compartmentalized signalling.

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John F Hancock Research Topics

Disease

34	Neoplasms (Cancer) 12/2021 - 02/2007
5	Pancreatic Neoplasms (Pancreatic Cancer) 12/2021 - 01/2018
4	Carcinogenesis 12/2021 - 01/2017
2	Sarcoma (Soft Tissue Sarcoma) 01/2021 - 06/2013
2	Colonic Neoplasms (Colon Cancer) 10/2020 - 01/2019
2	Endometrial Neoplasms (Endometrial Cancer) 12/2013 - 01/2013
1	Hepatitis C 12/2021
1	Lymphoma (Lymphomas) 11/2020
1	Multiple Sclerosis 01/2020
1	Glioma (Gliomas) 01/2020
1	Hepatocellular Carcinoma (Hepatoma) 01/2019
1	Carcinoma (Carcinomatosis) 01/2019
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2019
1	Colorectal Neoplasms (Colorectal Cancer) 01/2019
1	Hematologic Neoplasms (Hematological Malignancy) 01/2019
1	Uveal melanoma 01/2019
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2019
1	Lung Neoplasms (Lung Cancer) 01/2017
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2016
1	Melanoma (Melanoma, Malignant) 01/2016
1	Neuroblastoma 08/2015
1	Breast Neoplasms (Breast Cancer) 01/2014
1	Muscular Dystrophies (Muscular Dystrophy) 03/2008
1	Rupture 02/2008
1	Prostatic Neoplasms (Prostate Cancer) 01/2008
1	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 05/2002
1	1 Rippling muscle disease 05/2002

Drug/Important Bio-Agent (IBA)

7	Proteins (Proteins, Gene)FDA Link 12/2021 - 03/2008
7	neratinibIBA 01/2021 - 01/2019
7	ras ProteinsIBA 01/2020 - 04/2012
6	Protein Isoforms (Isoforms)IBA 01/2021 - 02/2007
5	PhosphatidylserinesIBA 12/2021 - 07/2013
4	LipidsIBA 12/2021 - 01/2014
3	Monomeric GTP-Binding ProteinsIBA 01/2021 - 02/2019
3	Phosphotransferases (Kinase)IBA 01/2021 - 01/2019
3	Beclin-1IBA 11/2020 - 01/2019
3	Pharmaceutical PreparationsIBA 01/2020 - 03/2016
2	phosphatidylinositol 4-phosphateIBA 12/2021 - 01/2021
2	regorafenibIBA 01/2021 - 01/2019
2	Guanosine Triphosphate (GTP)IBA 01/2021 - 01/2016
2	ezrinIBA 11/2020 - 01/2019
2	Histone Deacetylase InhibitorsIBA 11/2020 - 12/2019
2	Biological ProductsIBA 10/2019 - 01/2017
2	Sildenafil Citrate (Viagra)FDA Link 01/2019 - 12/2016
2	FendilineIBA 01/2018 - 01/2013
2	Mitogen-Activated Protein KinasesIBA 01/2016 - 08/2015
2	Caveolin 3IBA 03/2008 - 05/2002
2	CaveolinsIBA 01/2008 - 05/2002
1	SimeprevirIBA 12/2021
1	Antiviral Agents (Antivirals)IBA 12/2021
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2021
1	Carrier Proteins (Binding Protein)IBA 12/2021
1	CytokinesIBA 07/2021
1	Sorafenib (BAY 43-9006)FDA Link 01/2021
1	HydrolasesIBA 01/2021
1	Drug CombinationsIBA 01/2021
1	ErbB Receptors (EGF Receptor)IBA 10/2020
1	Dimethyl FumarateIBA 01/2020
1	Valproic Acid (Depakote)FDA LinkGeneric 01/2020
1	Fingolimod Hydrochloride (FTY720)FDA Link 01/2020
1	Temozolomide (Temodar)FDA LinkGeneric 01/2020
1	raf KinasesIBA 12/2019
1	Histone Deacetylases (Histone Deacetylase)IBA 12/2019
1	LigandsIBA 12/2019
1	EnzymesIBA 01/2019
1	CholesterolIBA 01/2019
1	Cathepsin BIBA 01/2019
1	Adenosine Monophosphate (AMP)IBA 01/2019
1	Protein Kinases (Protein Kinase)IBA 01/2019
1	AfatinibIBA 01/2019
1	entinostat (MS 275)IBA 01/2019
1	Caspase 9IBA 01/2019
1	Phosphodiesterase 5 InhibitorsIBA 01/2019
1	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 01/2018
1	AcidsIBA 01/2018
1	sphingosine kinaseIBA 01/2018
1	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2018
1	Oncogene Proteins (Oncogene Protein)IBA 01/2017
1	Antineoplastic Agents (Antineoplastics)IBA 01/2017
1	Deubiquitinating EnzymesIBA 01/2017
1	Cyclin EIBA 01/2017
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2016
1	PolyketidesIBA 07/2014
1	1-dodecylpyridoxal (PLD)IBA 01/2014
1	phospholipase D2IBA 01/2014
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2014
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2014
1	Phosphatidic Acids (Phosphatidic Acid)IBA 01/2014
1	Epidermal Growth Factor (EGF)IBA 01/2014
1	Metformin (Glucophage)FDA LinkGeneric 12/2013
1	BiguanidesIBA 12/2013
1	7-hydroxystaurosporine (UCN 01)IBA 07/2013
1	StaurosporineIBA 07/2013
1	DysferlinIBA 03/2008
1	MorpholinosIBA 02/2008

Therapy/Procedure

8	Therapeutics 05/2021 - 12/2013
1	Neoadjuvant Therapy 10/2020
1	Precision Medicine 01/2019
1	Drug Therapy (Chemotherapy) 01/2017